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The hospital germ Pseudomonas aeruginosa can cause serious wound as well as lung and urinary tract infections, especially in weakened individuals.
Pseudomonas manages time and again to survive attacks of the immune system and antibiotic therapies. Meine stadt würzburg single frauen key to the success of this persistent pathogen is its complex communication system as the bacteria use various signalling substances to communicate with each other and to control infection processes.
The ability of a single protein complex to change its shape allows the bacteria to process molecules of different sizes into signalling substances. The scientists published their results in ChemBioChem.
The detail enlargement shows that the channel has an optimal length for binding a fatty acid chain of eight carbon atoms. Pseudomonas bacteria can colonise and proliferate in virtually any environment, including the lungs, eyes, urinary tract, an open wound or an implant.
They even manage to survive most antibiotics by shielding themselves in a dense biofilm or by simply pumping the toxins from their interior with the help of small pumps. The bacteria communicate with each other when they select the effective survival strategies to be used. For this reason, scientists throughout the world are searching for properties that are specific to these bacteria and can be used as points of attack of novel medications.
One very promising target is one of the communication systems — the so-called pqs system Pseudomonas quinolone signalwhich is present as leute kennenlernen fürth only in P.
It has been known for a long time that this system works with a broad range of signalling molecules, but it was not known in detail how the diversity of these molecules arises. It produces molecules that have similar structures, but differ in the length of their fatty acids chains, although the exact molecular details of this were previously meine stadt würzburg single frauen.
In order to take a look behind the curtains of this versatile protein complex, Florian Witzgall, who is a doctoral student in Flirtportale kostenlos österreich department, carefully purified the protein complex and then crystallised it and determined the three-dimensional structure of PqsBC using x-ray diffraction analysis.
He was also able to identify different intermediate states and to derive that the regions of the protein complex surrounding the binding side of the fatty acid chains are the mobile part of the protein complex. If we manage to freeze the mobility of PqsBC with an agent, we would be able to specifically inhibit PqsBC and disrupt the communication of P.
The three-dimensional structure of the protein complex also demonstrates that the length of the channel is such that it is filled up by a fatty acid chain consisting of eight carbon atoms. A quantitative analysis of the converted fatty acids showed that chains made up leute chemnitz kennenlernen eight carbon atoms are incorporated single samenspende frequently.
The large diversity of the signalling bekanntschaften sankt augustin presumably meine stadt würzburg single frauen to the fact that both shorter and longer fatty acids fit into the channel and can be processed, albeit less efficiently.
The new insights into the mobility of PqsBC might open up a new target site for novel medications. PqsBC meine stadt würzburg single frauen in different conformational states. Computer simulations can be used to derive a dynamic mechanism from these states, in which PqsBC can bind to the meine stadt würzburg single frauen acid chain by closing the molecule. HZI researchers investigated the formation of signalling substances in Pseudomonas and einweihungsgeschenk single mann a target for novel medications The hospital germ Pseudomonas aeruginosa can cause serious wound as well as lung and urinary tract infections, especially in weakened individuals.
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